In 2013, we published our first list of 50 Mainers who have made a difference in our state. This feature story gathered together an assortment of bold thinkers and generous spirits, people who have contributed to their communities in deep and lasting ways. While we remain proud of our inaugural list, we knew that it was far from comprehensive. There are many more remarkable individuals living and working in Maine. Many more to learn from and be inspired by. Many more to honor and thank. Here, we celebrate a fraction of that illustrious population, those who are moving Maine forward through their innovative business practices, commitment to purpose-driven education, lifelong support of the arts, and groundbreaking medical research. We highlight philanthropists who have spent decades improving the inner workings of nonprofits, doctors who have found new ways to combat childhood obesity, and CEOs who are striving to create safer and more community-minded workplaces. We present to you 50 people who have changed our world, improved our lives, and broadened our horizons.